There's a bunch of sliders off to the right and more options a click a way. All of this can be pretty overwhelming.
I'm going to click on the "Preview" button to get a box where I can preview what the current settings will do.
Luckily, there a a bunch of "presets" too that make it easier on people that don't understand all the technical jargon by the sliders. I don't totally understand all of it myself. I'm going to go up to the down arrow below the "Filter Preset" field and pull down a menu and select "Remove all noise". It is pretty straightforward what this will do, it will plug in the numbers to remove all noise, like it says. The interface allow for beginners to do some basic things or a lot of control for advanced users.

I see a preview of what the settings will do in the "preview box". All of the noise has been removed and this is what I want so I'm going to click on "Apply" to apply the filter with the current settings to the image.

This is the result of Neat Image with the "Remove all noise" preset. All the noise has been removed, though I may have gone overboard and I sacrificed some of the details in the image to remove all the noise. Many times there's a tradeoff when you have a very noisy image. You have to try to find the right balance where you remove a good amount of noise, but still have good detail. I would probably go back and try and fine tune the controls better and turn down the noise removal a bit to maintain the detail. I will show you later in this tutorial how to selectively apply noise filters throughout the image.

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