Now I'll show you a couple of ways to selectively apply a reduce noise filter.
One way is to create a duplicate layer of your image and apply the noise reducing filter to the top layer. Then, use the "Eraser" tool to delete parts of the image on the top layer where you don't want the noise reduction. The bottom layer without the noise reduction will show through the erased parts of the top layer.
As you can see, there's a lot of noise in the sky of this image.

I'm going to duplicate this layer by dragging the layer onto the "Create a new layer" icon in the "Layers Palette". Alternatively, I could just press Ctrl-J and it will do the same thing.
Any noise reduction filter will work for this, I'm going to use Neat Image Pro. I'll access it by going to the "Filter" menu, sliding down to "Neat Image" and then over to "Reduce Noise".

I get this dialog box. I'll click on the "Auto Profile" button near the top to automatically create a noise profile.

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